Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) – Pipeline Review, H2 2016

Global Markets Direct’s, ‘Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) – Pipeline Review, H2 2016’, provides in depth analysis on Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted pipeline therapeutics.

The report provides comprehensive information on the Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) , targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. The report also covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases. Additionally, the report provides an overview of key players involved in Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted therapeutics development and features dormant and discontinued projects.

Global Markets Direct’s report features investigational drugs from across globe covering over 20 therapy areas and nearly 3,000 indications. The report is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Drug profiles featured in the report undergoes periodic review following a stringent set of processes to ensure that all the profiles are updated with the latest set of information. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

The report helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage.

Note:

Certain sections in the report may be removed or altered based on the availability and relevance of data.

Updated report will be delivered in 48 hours of order confirmation.

Scope

The report provides a snapshot of the global therapeutic landscape for Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8)

The report reviews Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages

The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities

The report reviews key players involved in Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted therapeutics and enlists all their major and minor projects

The report assesses Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type

The report summarizes all the dormant and discontinued pipeline projects

The report reviews latest news and deals related to Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) targeted therapeutics

Reasons to buy

Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies

Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

Identify and understand the targeted therapy areas and indications for Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8)

Identify the use of drugs for target identification and drug repurposing

Identify potential new clients or partners in the target demographic

Develop strategic initiatives by understanding the focus areas of leading companies

Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics

Devise corrective measures for pipeline projects by understanding Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC 5.2.1.8) development landscape

Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Companies mentioned

ContraVir Pharmaceuticals Inc

Cypralis Ltd

Debiopharm International SA

Enanta Pharmaceuticals Inc

Ensemble Therapeutics Corp

Table of Contents

Table of Contents

Table of Contents 2

List of Tables 4

List of Figures 4

Introduction 5

Global Markets Direct Report Coverage 5

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) Overview 6

Therapeutics Development 7

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Products under Development by Stage of Development 7

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Products under Development by Therapy Area 8

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Products under Development by Indication 9

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Pipeline Products Glance 10

Early Stage Products 10

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Products under Development by Companies 11

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Therapeutics Assessment 13

Assessment by Monotherapy/Combination Products 13

Assessment by Mechanism of Action 14

Assessment by Route of Administration 15

Assessment by Molecule Type 16

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Companies Involved in Therapeutics Development 18

ContraVir Pharmaceuticals Inc 18

Cypralis Ltd 19

Debiopharm International SA 20

Enanta Pharmaceuticals Inc 21

Ensemble Therapeutics Corp 22

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Drug Profiles 23

alisporivir - Drug Profile 23

Product Description 23

Mechanism Of Action 23

R&D Progress 23

alisporivir + EDP-239 - Drug Profile 26

Product Description 26

Mechanism Of Action 26

R&D Progress 26

CRV-431 - Drug Profile 27

Product Description 27

Mechanism Of Action 27

R&D Progress 27

Small Molecules to Inhibit Cyclophilin A for Hepatitis B - Drug Profile 30

Product Description 30

Mechanism Of Action 30

R&D Progress 30

Small Molecules to Inhibit Cyclophilin A for Inflammation - Drug Profile 31

Product Description 31

Mechanism Of Action 31

R&D Progress 31

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Dormant Projects 32

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Discontinued Products 33

Peptidyl Prolyl Cis Trans Isomerase A (Cyclophilin A or Cyclosporin A Binding Protein or Rotamase A or PPIA or EC

5.2.1.8) - Featured News & Press Releases 34

Dec 08, 2016: ContraVirs Cyclophilin Inhibitor CRV431 Potently Inhibits Essential Pathway in Hepatitis B 34

Sep 12, 2016: ContraVir Reports New CRV431 Data Highlighting Synergistic Activity with CMX157 Against Hepatitis B 34

Aug 22, 2016: ContraVir to Release New CRV431 Data Highlighting Potential Synergy with CMX157 Against Hepatitis B 35

Apr 19, 2016: Ciclofilin Pharmaceuticals Invited to Present Hepatitis B Drug Data at Cambridge Healthtech Institute’s Eleventh Annual Drug Discovery Chemistry Conference 36

Feb 04, 2016: Ciclofilin Pharmaceuticals Welcomes Dr. Nikolai Naoumov to Its Scientific Advisory Board 36

Dec 02, 2015: Ciclofilin Pharmaceuticals Announces Formation of World-Class HBV and Liver Disease Scientific Advisory Board 37

Nov 30, 2015: Ciclofilin Pharmaceuticals to Present at HEP DART 2015 39

Sep 08, 2015: Debiopharm International and Solid Biosciences Announce a Collaboration to Explore the Use of Alisporivir in Muscular Dystrophy 40

Aug 04, 2015: Ciclofilin Pharmaceuticals Receives Notice of Patent Allowance for Novel Cyclophilin Inhibitor 40

Jul 28, 2015: Ciclofilin Pharmaceuticals' Lead Antiviral Drug Reduces Liver HBV DNA 41

Jun 24, 2015: Ciclofilin Pharmaceuticals' HBV Drug Demonstrates Anti-Fibrotic Activity 41

Feb 24, 2015: Ciclofilin Pharmaceuticals Granted Patent in Japan for Cyclophilin Inhibitor Drugs 42

Feb 17, 2015: Ciclofilin Pharmaceuticals to Present HBV/HIV/HCV Co-Infection Results at EASL 2015 42

Nov 13, 2014: The Government of Canada Provides Support to Ciclofilin Pharmaceuticals for the Pre-Clinical Development of Its Lead Drug 43

Nov 04, 2014: Ciclofilin Pharmaceuticals to Present HIV/HCV Co-Infection Results at AASLD in Boston on November 11 43

Appendix 45

Methodology 45

Coverage 45

Secondary Research 45

Primary Research 45

Expert Panel Validation 45

Contact Us 45

Disclaimer 46

List of Tables

List of Tables

Number of Products under Development for, H2 2016 7

Number of Products under Development by Therapy Area, H2 2016 8

Number of Products under Development by Indication, H2 2016 9

Comparative Analysis by Early Stage Products, H2 2016 10

Number of Products under Development by Companies, H2 2016 11

Products under Development by Companies, H2 2016 12

Assessment by Monotherapy/Combination Products, H2 2016 13

Number of Products by Stage and Mechanism of Action, H2 2016 14

Number of Products by Stage and Route of Administration, H2 2016 15

Number of Products by Stage and Molecule Type, H2 2016 17

Pipeline by ContraVir Pharmaceuticals Inc, H2 2016 18

Pipeline by Cypralis Ltd, H2 2016 19

Pipeline by Debiopharm International SA, H2 2016 20

Pipeline by Enanta Pharmaceuticals Inc, H2 2016 21

Pipeline by Ensemble Therapeutics Corp, H2 2016 22

Dormant Projects, H2 2016 32

Discontinued Products, H2 2016 33

List of Figures

List of Figures

Number of Products under Development for, H2 2016 7

Number of Products under Development by Therapy Area, H2 2016 8

Number of Products under Development by Indication, H2 2016 9

Comparative Analysis by Early Stage Products, H2 2016 10

Assessment by Monotherapy/Combination Products, H2 2016 13

Number of Products by Stage and Mechanism of Actions, H2 2016 14

Number of Products by Molecule Types, H2 2016 16

Number of Products by Stage and Molecule Type, H2 2016 16

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