Growth Hormone Secretagogue Receptor Type 1 – Drugs In Development, 2021

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) pipeline Target constitutes close to 15 molecules. Out of which approximately 14 molecules are developed by companies and remaining by the universities/institutes. The latest report Growth Hormone Secretagogue Receptor Type 1 – Drugs In Development, 2021, outlays comprehensive information on the Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) – Growth hormone secretagogue receptor (GHSR) also known as ghrelin receptor, is a G protein-coupled receptor that binds ghrelin. Ghrelin is an appetite-regulating factor secreted from peripheral organs via binding to the receptor resulting in the secretion of growth hormone by the pituitary gland. The pathway activated by binding of ghrelin to the growth hormone secretagogue receptor, GHSR1a, regulates the activation of the downstream mitogen-activated protein kinase, Akt, nitric oxide synthase, and AMPK cascades in different cellular systems. Inverse agonists for the ghrelin receptor could be particularly interesting for the treatment of obesity. The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 1, 4, 1, 7 and 1 respectively. Similarly, the universities portfolio in Phase II stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Central Nervous System, Toxicology, Cardiovascular, Genetic Disorders, Hormonal Disorders, Gastrointestinal, Genito Urinary System And Sex Hormones, Infectious Disease, Metabolic Disorders, Musculoskeletal Disorders and Women's Health which include indications Cancer Anorexia-Cachexia Syndrome, Growth Hormone Deficiency, Radiation Toxicity (Radiation Sickness, Acute Radiation Syndrome), Acute Ischemic Stroke, Alcohol Addiction, Amyotrophic Lateral Sclerosis, Born Small For Gestational Age (SGA), Cachexia, Chemotherapy Effects, Chronic Kidney Disease (Chronic Renal Failure), Constipation, Endocrine Gland Disorders, Fatigue, Ischemia, Obesity, Prader-Willi Syndrome (PWS), Sepsis, Traumatic Brain Injury and Turner Syndrome.

Furthermore, this report also reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

– The report provides a snapshot of the global therapeutic landscape for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)

– The report reviews Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources

– The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages

– The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities

– The report reviews key players involved in Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics and enlists all their major and minor projects

– The report assesses Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type

– The report summarizes all the dormant and discontinued pipeline projects

– The report reviews latest news and deals related to Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies

- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage

- Identify and understand the targeted therapy areas and indications for Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR)Identify the use of drugs for target identification and drug repurposing

- Identify potential new clients or partners in the target demographic

- Develop strategic initiatives by understanding the focus areas of leading companies

- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics

- Devise corrective measures for pipeline projects by understanding Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) development landscape

- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

Companies mentioned

Aeterna Zentaris Inc

AstraZeneca Plc

Extend Biosciences Inc

Helsinn Group

Lumos Pharma Inc

Oxeia Biopharmaceuticals Inc

Pfizer Inc

RaQualia Pharma Inc

Tempest Therapeutics Inc

TheraSource LLC

Zeria Pharmaceutical Co Ltd

Table of Contents

Table of Contents

List of Tables

List of Figures

Introduction

Global Markets Direct Report Coverage

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Overview

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Therapeutics Development

Products under Development by Stage of Development

Products under Development by Therapy Area

Products under Development by Indication

Products under Development by Companies

Products under Development by Universities/Institutes

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Therapeutics Assessment

Assessment by Mechanism of Action

Assessment by Route of Administration

Assessment by Molecule Type

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Companies Involved in Therapeutics Development

Aeterna Zentaris Inc

AstraZeneca Plc

Extend Biosciences Inc

Helsinn Group

Lumos Pharma Inc

Oxeia Biopharmaceuticals Inc

Pfizer Inc

RaQualia Pharma Inc

Tempest Therapeutics Inc

TheraSource LLC

Zeria Pharmaceutical Co Ltd

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Drug Profiles

anamorelin hydrochloride - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

AZ-12861903 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

EXT-405 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

EXT-418 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

HM-04 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

ibutamoren mesylate - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

livoletide - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

macimorelin acetate - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

OXE-103 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Peptide to Agonize GHSR for Acute Ischemic Stroke, Acute Radiation Syndrome and Sepsis - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

PF-05190457 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

RQ-00433412 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Small Molecules to Agonize GHSR for Cachexia - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Synthetic Peptide to Modulate GHSR for Chronic Kidney Disease - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Z-505 - Drug Profile

Product Description

Mechanism Of Action

R&D Progress

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Dormant Products

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Discontinued Products

Growth Hormone Secretagogue Receptor Type 1 (GH Releasing Peptide Receptor or Ghrelin Receptor or GHSR) - Product Development Milestones

Featured News & Press Releases

Jun 28, 2021: Lumos Pharma announces OraGrowtH212 trial of LUM-201 in PGHD is open for enrollment

Jun 03, 2021: Aeterna Zentaris announces final settlement of previously disclosed class-action lawsuit

May 17, 2021: Aeterna Zentaris announces the start of preclinical development of Macimorelin at The University of Queensland as a potential new treatment option for patients with amyotrophic lateral sclerosis (ALS, Lou Gehrig’s Disease)

May 13, 2021: Aeterna Zentaris commences pivotal phase 3 DETECT-trial for the diagnosis of childhood-onset growth hormone deficiency

Apr 27, 2021: Newly released data on three PGHD patients treated with LUM-201 in prior phase 2 study to be presented in Lumos Pharma Key Opinion Leader Webinar

Apr 21, 2021: Launch of Adlumiz (anamorelin), a Ghrelin Receptor Agonist in Japan

Apr 14, 2021: Lumos Pharma to host key opinion leader event on LUM-201 for the treatment of pediatric growth hormone deficiency

Mar 20, 2021: Data presented at ENDO 2021 differentiate LUM-201 from standard growth hormone secretagogues and further support LUM-201’s potential as a therapeutic for pediatric growth hormone deficiency

Mar 04, 2021: Data supporting use of predictive enrichment markers for Lumos Pharma’s LUM-201 therapy in clinical trials for moderate PGHD published in Journal of the Endocrine Society

Mar 02, 2021: Lumos Pharma to present poster demonstrating greater GH response to LUM-201 than to standard GH secretagogues in PGHD at the Endocrine Society (ENDO) 2021 annual meeting

Jan 22, 2021: ONO receives a manufacturing and marketing approval of Adlumiz (anamorelin), a ghrelin receptor agonist for the treatment of cancer cachexia in Japan

Oct 21, 2020: Oxeia Biopharmaceuticals announces initiation of phase 2 trial for OXE103 for the treatment of concussions

Sep 16, 2020: Aeterna Zentaris provides corporate update

Sep 08, 2020: Aeterna Zentaris announced presentation of positive results from first pediatric study of Macimorelin at the 22nd European Congress of Endocrinology

Jul 31, 2020: Aeterna Zentaris announces continued expansion of intellectual property portfolio for Macimorelin with additional patent applications

Appendix

Methodology

Coverage

Secondary Research

Primary Research

Expert Panel Validation

Contact Us

Disclaimer

List of Tables

List of Tables

Number of Products under Development by Stage of Development, 2021

Number of Products under Development by Therapy Areas, 2021

Number of Products under Development by Indication, 2021

Number of Products under Development by Companies, 2021

Products under Development by Companies, 2021

Products under Development by Companies, 2021 (Contd..1)

Number of Products under Investigation by Universities/Institutes, 2021

Products under Investigation by Universities/Institutes, 2021

Number of Products by Stage and Mechanism of Actions, 2021

Number of Products by Stage and Route of Administration, 2021

Number of Products by Stage and Molecule Type, 2021

Pipeline by Aeterna Zentaris Inc, 2021

Pipeline by AstraZeneca Plc, 2021

Pipeline by Extend Biosciences Inc, 2021

Pipeline by Helsinn Group, 2021

Pipeline by Lumos Pharma Inc, 2021

Pipeline by Oxeia Biopharmaceuticals Inc, 2021

Pipeline by Pfizer Inc, 2021

Pipeline by RaQualia Pharma Inc, 2021

Pipeline by Tempest Therapeutics Inc, 2021

Pipeline by TheraSource LLC, 2021

Pipeline by Zeria Pharmaceutical Co Ltd, 2021

Dormant Products, 2021

Dormant Products, 2021 (Contd..1)

Dormant Products, 2021 (Contd..2)

Discontinued Products, 2021

List of Figures

List of Figures

Number of Products under Development by Stage of Development, 2021

Number of Products under Development by Therapy Areas, 2021

Number of Products under Development by Top 10 Indications, 2021

Number of Products by Mechanism of Actions, 2021

Number of Products by Stage and Mechanism of Actions, 2021

Number of Products by Routes of Administration, 2021

Number of Products by Stage and Routes of Administration, 2021

Number of Products by Molecule Types, 2021

Number of Products by Stage and Molecule Types, 2021

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